T helper cells subsets;
umbilical cord blood;
interleukin-4;
interleukin-5;
atopy;
D O I:
10.1002/eji.1830261004
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
T cell clones were generated from umbelical cord blood lymphocytes (UCBL) of nine newborns with atopic or nonatopic parents and their cytokine secretion profile was assessed. Both phytohemagglutinin-induced and Dermatophagoides pteronyssinus-specific T cell clones from newborns with atopic parents exhibited an enhanced ability to produce the Th2 cytokines interleukin (IL)-4 and IL-5, compared to T cell clones from newborns with nonatopic parents. In contrast, the ability to produce interferon-gamma by UCBL from the two groups of newborns was not different. Of the five children who could be followed up to 3 years after birth, four with atopic parents developed clinical and/or biological atopic manifestations, whereas one without atopic parents did not. Thus, the pronounced production of IL-4 and IL-5 by UCBL not only appears to be related to the atopic status of parents, but also associates with the subsequent development of atopy in childhood.
机构:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADAUNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA
DEMEURE, CE
YANG, LP
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADAUNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA
YANG, LP
BYUN, DG
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADAUNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA
BYUN, DG
ISHIHARA, H
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADAUNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA
ISHIHARA, H
VEZZIO, N
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADAUNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA
VEZZIO, N
DELESPESSE, G
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADAUNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA
机构:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADAUNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA
DEMEURE, CE
YANG, LP
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADAUNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA
YANG, LP
BYUN, DG
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADAUNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA
BYUN, DG
ISHIHARA, H
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADAUNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA
ISHIHARA, H
VEZZIO, N
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADAUNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA
VEZZIO, N
DELESPESSE, G
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADAUNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,MONTREAL,PQ H2L 4M1,CANADA