Abnormal production of T helper 2 cytokines interleukin-4 and interleukin-5 by T-cells from newborns with atopic parents

被引:59
作者
Piccinni, MP
Beloni, L
Giannarini, L
Livi, C
Scarselli, G
Romagnani, S
Maggi, E
机构
[1] UNIV FLORENCE,INST INTERNAL MED & IMMUNOALLERGOL,DEPT CLIN IMMUNOL,I-50134 FLORENCE,ITALY
[2] UNIV FLORENCE,INST OBSTET & GYNECOL,FLORENCE,ITALY
关键词
T helper cells subsets; umbilical cord blood; interleukin-4; interleukin-5; atopy;
D O I
10.1002/eji.1830261004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
T cell clones were generated from umbelical cord blood lymphocytes (UCBL) of nine newborns with atopic or nonatopic parents and their cytokine secretion profile was assessed. Both phytohemagglutinin-induced and Dermatophagoides pteronyssinus-specific T cell clones from newborns with atopic parents exhibited an enhanced ability to produce the Th2 cytokines interleukin (IL)-4 and IL-5, compared to T cell clones from newborns with nonatopic parents. In contrast, the ability to produce interferon-gamma by UCBL from the two groups of newborns was not different. Of the five children who could be followed up to 3 years after birth, four with atopic parents developed clinical and/or biological atopic manifestations, whereas one without atopic parents did not. Thus, the pronounced production of IL-4 and IL-5 by UCBL not only appears to be related to the atopic status of parents, but also associates with the subsequent development of atopy in childhood.
引用
收藏
页码:2293 / 2298
页数:6
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