Electrostatic self-assembly of nanocomposite hybrid fluorescent sensors

被引：2

作者：

Brown, JQ ^{[1
]}

Guice, KB ^{[1
]}

Simpson, RT ^{[1
]}

McShane, MJ ^{[1
]}

机构：

[1] Louisiana Tech Univ, Biomed Engn Program, Ruston, LA 71272 USA

来源：

NANOBIOPHOTONICS AND BIOMEDICAL APPLICATIONS | 2004年 / 5331卷

关键词：

self-assembly; nanoprobes; fluorescence; biosensing;

D O I：

10.1117/12.529793

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Nanofabrication is an attractive tool for precise construction of micro/nanostructures to realize fluorescence sensors that may overcome problems related to use of free dyes for biological analysis. Sensor films deposited on optically-functional nanotemplates (<300nm) are proposed as intracellular chemical sensors that provide an internal standard and stable separation of host from toxic foreign materials. Fluorescent nanoparticles were used as templates and intensity references for oxygen- and pH-sensitive fluorophores {Ru(dpp), HPTS}, and potassium and sodium-binding dyes (PBFI, Sodium Green). Nanoassembled films on particles were characterized in terms of response to target analytes. These findings suggest that self-assembled nanoparticle sensors may be easily produced and employed as useful tools for real-time cellular analysis.

引用

页码：52 / 59

页数：8

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