Prefrontal cortex atrophy predicts dementia over a six-year period

被引：47

作者：

Burgmans, S. ^{[1
,3
]}

van Boxtel, M. P. J. ^{[1
,3
]}

Smeets, F. ^{[1
,3
]}

Vuurman, E. F. P. M. ^{[1
,3
]}

Gronenschild, E. H. B. M. ^{[1
,3
]}

Verhey, F. R. J. ^{[1
,3
]}

Uylings, H. B. M. ^{[1
,2
,3
]}

Jolles, J. ^{[1
,3
]}

机构：

[1] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Dept Anat & Neurosci, NL-1007 MB Amsterdam, Netherlands

[3] Maastricht Univ, European Grad Sch Neurosci EURON, NL-6200 MD Maastricht, Netherlands

来源：

NEUROBIOLOGY OF AGING | 2009年 / 30卷 / 09期

关键词：

Prefrontal cortex; Dementia; Alzheimer's disease; Medial temporal lobe; Gray matter atrophy; Cognitive decline; Aging; Volumetry; MRI; MILD COGNITIVE IMPAIRMENT; TEMPORAL-LOBE ATROPHY; ALZHEIMER-DISEASE; INDIVIDUAL-DIFFERENCES; MRI DATA; VOLUMES; SCALE; GRAY;

D O I：

10.1016/j.neurobiolaging.2007.11.028

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The present study investigated prefrontal cortex (PFC) atrophy as a possible predictor of dementia. Eighty-eight older participants of the Maastricht Aging Study (MAAS) were administered for neuropsychological tests at baseline and after three years (t(3)). Magnetic resonance images were acquired at t(3) and nine years after baseline all participants were screened for dementia. Three groups were distinguished: (1) participants who did not develop dementia or cognitive decline, (2) participants who did not develop dementia but did show significant cognitive decline, and (3) participants who developed dementia. Gray matter volume of structures in the PFC and medial temporal lobe (MTL) was measured. Prefrontal volume was significantly smaller in group 3 than in the other two groups, and PFC volume was significantly better than MTL volume in distinguishing between groups 2 and 3. These findings suggest that PFC atrophy is highly associated with dementia and can be considered an important predictor of the disease. It may even be a better predictor than the MTL atrophy that has been found in earlier studies. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：1413 / 1419

页数：7

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