Practice Parameter update: Management issues for women with epilepsy-Focus on pregnancy (an evidence-based review): Obstetrical complications and change in seizure frequency Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society

被引：159

作者：

Harden, C. L. ^{[1
]}

Hopp, J. ^{[2
]}

Ting, T. Y. ^{[2
]}

Pennell, P. B. ^{[3
]}

French, J. A. ^{[4
]}

Hauser, W. A. ^{[5
]}

Wiebe, S. ^{[6
]}

Gronseth, G. S. ^{[7
]}

Thurman, D. ^{[8
]}

Meador, K. J. ^{[3
]}

Koppel, B. S. ^{[9
]}

Kaplan, P. W. ^{[10
]}

Robinson, J. N. ^{[11
]}

Gidal, B. ^{[12
]}

Hovinga, C. A. ^{[13
]}

Wilner, A. N.

Vazquez, B.

Holmes, L. ^{[11
]}

Krumholz, A. ^{[2
]}

Finnell, R. ^{[14
]}

Le Guen, C. ^{[15
]}

机构：

[1] Univ Miami, Miami, FL USA

[2] Univ Maryland, Baltimore, MD 21201 USA

[3] Emory Univ, Atlanta, GA 30322 USA

[4] NYU, Sch Med, New York, NY USA

[5] Columbia Univ, New York, NY USA

[6] Univ Calgary, Calgary, AB T2N 1N4, Canada

[7] Univ Kansas, Med Ctr, Kansas City, KS 66103 USA

[8] Ctr Dis Control & Prevent, Atlanta, GA USA

[9] New York Med Coll, New York, NY USA

[10] Johns Hopkins Univ, Baltimore, MD USA

[11] Harvard Univ, Sch Med, Boston, MA USA

[12] Univ Wisconsin, Sch Pharm, Madison, WI 53706 USA

[13] Univ Tennessee, Hlth Sci Ctr, Memphis, TN USA

[14] Texas A&M Univ, Hlth Sci Ctr, College Stn, TX 77843 USA

[15] Univ Penn, Philadelphia, PA 19104 USA

来源：

NEUROLOGY | 2009年 / 73卷 / 02期

关键词：

PERSPECTIVE; PUERPERIUM; LIFE;

D O I：

10.1212/WNL.0b013e3181a6b2f8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including the risk of pregnancy complications or other medical problems during pregnancy in WWE compared to other women, change in seizure frequency, the risk of status epilepticus, and the rate of remaining seizure-free during pregnancy. Methods: A 20-member committee including general neurologists, epileptologists, and doctors in pharmacy evaluated the available evidence based on a structured literature review and classification of relevant articles published between 1985 and February 2008. Results: For WWE taking antiepileptic drugs, there is probably no substantially increased risk (greater than two times expected) of cesarean delivery or late pregnancy bleeding, and probably no moderately increased risk (greater than 1.5 times expected) of premature contractions or premature labor and delivery. There is possibly a substantially increased risk of premature contractions and premature labor and delivery during pregnancy for WWE who smoke. Seizure freedom for at least 9 months prior to pregnancy is probably associated with a high likelihood (84%-92%) of remaining seizure-free during pregnancy. Recommendations: Women with epilepsy (WWE) should be counseled that seizure freedom for at least 9 months prior to pregnancy is probably associated with a high rate (84%-92%) of remaining seizure-free during pregnancy (Level B). However, WWE who smoke should be counseled that they possibly have a substantially increased risk of premature contractions and premature labor and delivery during pregnancy (Level C). Neurology(R) 2009; 73: 126-132

引用

页码：126 / 132

页数：7

共 22 条

[1]

INCIDENCE OF SEIZURES DURING PREGNANCY, LABOR AND PUERPERIUM IN EPILEPTIC WOMEN - A PROSPECTIVE-STUDY [J].