Autophagy and caspase-independent cell death: p19ARF enters the game

被引：5

作者：

Codogno, P ^{[1
]}

机构：

[1] Univ Paris Sud, INSERM, U756, Chatenay Malabry 92296, France

来源：

DEVELOPMENTAL CELL | 2006年 / 10卷 / 06期

关键词：

D O I：

10.1016/j.devcel.2006.05.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ARF, often localized in the nucleolus, controls the p53 pathway and ribosomal biogenesis. In a recent issue of Molecular Cell, Kimchi and colleagues describe a short mitochondrial form of ARF (smARF), produced by internal initiation of translation, that dissipates mitochondrial membrane potential independently of p53 and Bcl-2 family members and triggers caspase-independent cell death. The prodeath function of smARF is dependent on the induction of autophagy.

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收藏

页码：688 / 689

页数：2

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