ANTIDotE: anti-tick vaccines to prevent tick-borne diseases in Europe

被引：37

作者：

Sprong, Hein ^{[1
]}

Trentelman, Jos ^{[2
]}

Seemann, Ingar ^{[2
]}

Grubhoffer, Libor ^{[3
]}

Rego, Ryan O. M. ^{[3
]}

Hajdusek, Ondrej ^{[3
]}

Kopacek, Petr ^{[3
]}

Sima, Radek ^{[3
]}

Nijhof, Ard M. ^{[4
]}

Anguita, Juan ^{[5
,6
]}

Winter, Peter ^{[7
]}

Rotter, Bjorn ^{[7
]}

Havlikova, Sabina ^{[8
]}

Klempa, Boris ^{[8
]}

Schetters, Theo P. ^{[9
]}

Hovius, Joppe W. R. ^{[2
]}

机构：

[1] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Ctr Expt & Mol Med, NL-1105 AZ Amsterdam, Netherlands

[3] Acad Sci Czech Republ, Ctr Biol, Ceske Budejovice, Czech Republic

[4] Free Univ Berlin, Inst Parasitol & Trop Vet Med, Berlin, Germany

[5] Ctr Cooperat Res Biosci CIC BioGUNE, Derio, Spain

[6] Ikerbasque Fdn, Bilbao, Spain

[7] GenXPro GmbH GenXPro, Frankfurt, Germany

[8] Slovak Acad Sci IV SAS, Inst Virol, Bratislava, Slovakia

[9] Merck Sharp & Dohme Anim Hlth, Boxmeer, Netherlands

来源：

PARASITES & VECTORS | 2014年 / 7卷

关键词：

Ixodes ricinus; Vaccine; Lyme borreliosis; Tick borne encephalitis; Babesiosis; Public health; IXODES-RICINUS; ENCEPHALITIS; VACCINATION; PROTEIN; TRANSMISSION; INFESTATIONS; PREVALENCE; RISK;

D O I：

10.1186/1756-3305-7-77

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程]; 100103 [病原生物学];

摘要：

Ixodes ricinus transmits bacterial, protozoal and viral pathogens, causing disease and forming an increasing health concern in Europe. ANTIDotE is an European Commission funded consortium of seven institutes, which aims to identify and characterize tick proteins involved in feeding and pathogen transmission. The knowledge gained will be used to develop and evaluate anti-tick vaccines that may prevent multiple human tick-borne diseases. Strategies encompassing anti-tick vaccines to prevent transmission of pathogens to humans, animals or wildlife will be developed with relevant stakeholders with the ultimate aim of reducing the incidence of tick-borne diseases in humans.

引用

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