Gonadotropin, ACTH, prolactin, sexual steroid and cortisol levels in postmenopausal women's cerebrospinal fluid (CSF)

In CSF and serum of 24 fertile (34.9 +/- 12.2 years) and 15 postmenopausal (58.9 +/- 6.9 years) female patients with non-inflammatory neurologic diseases, LH, FSH, ACTH, prolactin (Prol), estradiol (E), progesterone (P), testosterone (T), and cortisol (C) levels were determined by RIA. In postmenopause, serum levels of FSH and LH had 8- and 6-fold increases in comparison to those in reproductive age. In postmenopause, serum levels of E, P, ACTH and Prol had 8-, 5-, 3- and 2-fold decreases. Serum levels of T and C remained statistically unchanged during the whole life span. In postmenopause, CSF levels of FSH and LH had 3- and 2-fold increases, while E, P, Prol, ACTH CSF levels remained statistically unchanged compared to those in reproductive age (CSF-C levels were under the test sensitivities). CSF/serum ratio of FSH had a 4-fold decrease while that of E had a 4-fold increase in the postmenopause. CSF and serum levels of estradiol and ACTH as well as the logarithmic values of FSH, Prol and P concentrations correlated significantly regarding the whole reproductive postmenopausal life span, however, the CSF-blood barrier seemed to protect the brain from the effects of peripheral estradiol-progesterone deficiencies. (C) 1997 Elsevier Science Ireland Ltd.