Effects of statins on carotid disease and stroke

被引：12

作者：

Crouse, JR ^{[1
]}

机构：

[1] Wake Forest Univ, Sch Med, Dept Med, Winston Salem, NC 27157 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 1999年 / 10卷 / 06期

关键词：

D O I：

10.1097/00041433-199912000-00009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The results of recent trials indicate that statin treatment reduces not only the risk of coronary heart disease, but also the risk of stroke, in patients with existing heart disease. The need for the treatment of such patients is now generally recognized. Mechanisms for risk reduction include the retardation of plaque progression, plaque stabilization, and reducing the risk of coronary events. Questions remain regarding the discrepancy between epidemiological data and statin trials data, the precise mechanism of action of statins, and their role in the prevention of recurrent stroke in individuals who have experienced a previous stroke or transient ischemic attack but are free of coronary disease. Curr Opin Lipidol 10:535-541. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：535 / 541

页数：7

共 65 条

[1] ATHEROSCLEROTIC DISEASE OF THE AORTIC-ARCH AND THE RISK OF ISCHEMIC STROKE [J].

AMARENCO, P ;

COHEN, A ;

TZOURIO, C ;

BERTRAND, B ;

HOMMEL, M ;

BESSON, G ;

CHAUVEL, C ;

TOUBOUL, PJ ;

BOUSSER, MG .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (22) :1474-1479

[2]

[Anonymous], 1975, JAMA-J AM MED ASSOC, V231, P360

[3] CHOLESTEROL REDUCTION AND THE RISK FOR STROKE IN MEN - A METAANALYSIS OF RANDOMIZED, CONTROLLED TRIALS [J].

ATKINS, D ;

PSATY, BM ;

KOEPSELL, TD ;

LONGSTRETH, WT ;

LARSON, EB .

ANNALS OF INTERNAL MEDICINE, 1993, 119 (02) :136-145

[4] BENEFICIAL-EFFECTS OF COLESTIPOL-NIACIN THERAPY ON THE COMMON CAROTID-ARTERY - 2-YEAR AND 4-YEAR REDUCTION OF INTIMA-MEDIA THICKNESS MEASURED BY ULTRASOUND [J].

BLANKENHORN, DH ;

SELZER, RH ;

CRAWFORD, DW ;

BARTH, JD ;

LIU, CR ;

LIU, CH ;

MACK, WJ ;

ALAUPOVIC, P .

CIRCULATION, 1993, 88 (01) :20-28

[5] Stroke, statins, and cholesterol - A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors [J].

Blauw, GJ ;

Lagaay, AM ;

Smelt, AHM ;

Westendorp, RGJ .

STROKE, 1997, 28 (05) :946-950

[6] LIPID-LOWERING AND PLAQUE REGRESSION - NEW INSIGHTS INTO PREVENTION OF PLAQUE DISRUPTION AND CLINICAL EVENTS IN CORONARY-DISEASE [J].

BROWN, BG ;

ZHAO, XQ ;

SACCO, DE ;

ALBERS, JJ .

CIRCULATION, 1993, 87 (06) :1781-1791

[7] Effect of HMGcoA reductase inhibitors on stroke - A meta-analysis of randomized, controlled trials [J].

Bucher, HC ;

Griffith, LE ;

Guyatt, GH .

ANNALS OF INTERNAL MEDICINE, 1998, 128 (02) :89-+

[8] EFFECT OF PARTIAL ILEAL BYPASS-SURGERY ON MORTALITY AND MORBIDITY FROM CORONARY HEART-DISEASE IN PATIENTS WITH HYPERCHOLESTEROLEMIA - REPORT OF THE PROGRAM ON THE SURGICAL CONTROL OF THE HYPERLIPIDEMIAS (POSCH) [J].

BUCHWALD, H ;

VARCO, RL ;

MATTS, JP ;

LONG, JM ;

FITCH, LL ;

CAMPBELL, GS ;

PEARCE, MB ;

YELLIN, AE ;

EDMISTON, WA ;

SMINK, RD ;

SAWIN, HS ;

CAMPOS, CT ;

HANSEN, BJ ;

TUNA, N ;

KARNEGIS, JN ;

SANMARCO, ME ;

AMPLATZ, K ;

CASTANEDAZUNIGA, WR ;

HUNTER, DW ;

BISSETT, JK ;

WEBER, FJ ;

STEVENSON, JW ;

LEON, AS ;

CHALMERS, TC .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (14) :946-955

[9] REDUCTION IN CARDIOVASCULAR EVENTS DURING PRAVASTATIN THERAPY - POOLED ANALYSIS OF CLINICAL EVENTS OF THE PRAVASTATIN ATHEROSCLEROSIS INTERVENTION PROGRAM [J].

BYINGTON, RP ;

JUKEMA, JW ;

SALONEN, JT ;

PITT, B ;

BRUSCHKE, AV ;

HOEN, H ;

FURBERG, CD ;

MANCINI, J .

CIRCULATION, 1995, 92 (09) :2419-2425

[10] Effects of high doses of simvastatin and atorvastatin on high-density lipoprotein cholesterol and apolipoprotein A-I [J].

Crouse, JR ;

Frohlich, J ;

Ose, L ;

Mercuri, M ;

Tobert, JA .

AMERICAN JOURNAL OF CARDIOLOGY, 1999, 83 (10) :1476-+

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