Autophagy: a double-edged sword for neuronal survival after cerebral ischemia

被引：154

作者：

Chen, Wenqi ^{[1
]}

Sun, Yinyi ^{[1
]}

Liu, Kangyong ^{[2
]}

Sun, Xiaojiang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Neurol, Shanghai 200030, Peoples R China

[2] Zhoupu Hosp, Shanghai, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 12期

基金：

中国国家自然科学基金;

关键词：

nerve regeneration; autophagy; lysosome; autophagosome; neuron; cerebral ischemia; signaling pathway; apoptosis; necrosis; survival; NSFC grant; neural regeneration; INDUCED BRAIN-INJURY; NEONATAL HYPOXIA-ISCHEMIA; ACTIVATED PROTEIN-KINASE; CELL-DEATH; SIGNALING PATHWAY; RAT MODEL; DISEASE; APOPTOSIS; ROLES; NEUROPROTECTION;

D O I：

10.4103/1673-5374.135329

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects.

引用

页码：1210 / 1216

页数：7

共 72 条

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