Collective binding properties of receptor arrays

被引：30

作者：

Agmon, N

Edelstein, AL

机构：

[1] Department of Physical Chemistry, Fritz Haber Research Center, Hebrew University

来源：

BIOPHYSICAL JOURNAL | 1997年 / 72卷 / 04期

基金：

以色列科学基金会;

关键词：

END-PLATE CURRENTS; EXCITATORY SYNAPTIC TRANSMISSION; TIME-COURSE; ENDPLATE CURRENTS; NEUROMUSCULAR-JUNCTION; ACETYLCHOLINE-RECEPTORS; QUANTITATIVE SIMULATION; TRANSMITTER RELEASE; QUANTAL ANALYSIS; RAT HIPPOCAMPUS;

D O I：

10.1016/S0006-3495(97)78805-2

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Binding kinetics of receptor arrays can differ dramatically from that of the isolated receptor. We simulate synaptic transmission using a microscopically accurate Brownian dynamics routine. We study the factors governing the rise and decay of the activation probability as a function of the number of transmitter molecules released. Using a realistic receptor array geometry, the simulation reproduces the time course of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated excitatory postsynaptic currents. A consistent interpretation of experimentally observed synaptic currents in terms of rebinding and spatial correlations is discussed.

引用

页码：1582 / 1594

页数：13

共 63 条

[1] GEOMETRIC AND MANY-PARTICLE ASPECTS OF TRANSMITTER BINDING [J].