Pharmacological Treatment for Heart Failure: A View From the Brain

被引：43

作者：

Felder, R. B. ^{[1
,2
]}

Yu, Y. ^{[2
]}

Zhang, Z-H ^{[2
]}

Wei, S-G ^{[2
]}

机构：

[1] Dept Vet Affairs Med Ctr, Med Serv, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Internal Med, Div Cardiovasc Med, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2009年 / 86卷 / 02期

基金：

美国国家卫生研究院;

关键词：

RENIN-ANGIOTENSIN SYSTEM; SYMPATHETIC AFFERENT REFLEX; II TYPE-2 RECEPTOR; AT(1) RECEPTOR; UP-REGULATION; TNF-ALPHA; RATS; ACTIVATION; BLOCKADE; SYMPATHOEXCITATION;

D O I：

10.1038/clpt.2009.117

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Systolic heart failure is a feed-forward phenomenon with devastating consequences. Impaired cardiac function is the initiating event, but central nervous system mechanisms activated by persistent altered neural and humoral signals from the periphery play an important sustaining role. Animals with experimentally induced heart failure have neurochemical abnormalities in the brain that, when manipulated, profoundly affect sympathetic drive, volume regulation, and cardiac remodeling-critical determinants of outcome. This brief review explores recent studies that provide a strong rationale for the development of pharmaceutical agents that target central nervous system abnormalities in heart failure.

引用

页码：216 / 220

页数：5

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