Plasticity in the human central nervous system

被引：798

作者：

Cooke, S. F. ^{[1
]}

Bliss, T. V. P. ^{[1
]}

机构：

[1] Natl Inst Med Res, Div Neurophysiol, London NW7 1AA, England

来源：

BRAIN | 2006年 / 129卷

基金：

英国医学研究理事会;

关键词：

long-term potentiation; long-term depression; transcranial magnetic stimulation; interventional paired associative stimulation; NMDA receptor;

D O I：

10.1093/brain/awl082

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Long-term potentiation (LTP) is a well-characterized form of synaptic plasticity that fulfils many of the criteria for a neural correlate of memory. LTP has been studied in a variety of animal models and, in rodents in particular, there is now a strong body of evidence demonstrating common underlying molecular mechanisms in LTP and memory. Results are beginning to emerge from studies of neural plasticity in humans. This review will summarize findings demonstrating that synaptic LTP can be induced in human CNS tissue and that rodent and human LTP probably share similar molecular mechanisms. We will also discuss the application of non-invasive stimulation techniques to awake human subjects to induce LTP-like long-lasting changes in localized neural activity. These techniques have potential therapeutic application in manipulating neural plasticity to treat a variety of conditions, including depression, Parkinson's disease, epilepsy and neuropathic pain.

引用

页码：1659 / 1673

页数：15

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