Diabetic nephropathy: leveraging mouse genetics

被引：11

作者：

Breyer, Matthew D. ^{[1
]}

Qi, Zhonghua

Tchekneva, Elena

机构：

[1] Vanderbilt Univ, Dept Med, Div Nephrol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Dept Physiol & Mol Biophys, Nashville, TN 37232 USA

[3] Vet Adm Med Ctr, Nashville, TN 37203 USA

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2006年 / 15卷 / 03期

关键词：

albuminuria; diabetic complications; glycation; mutagenesis;

D O I：

10.1097/01.mnh.0000222687.75055.eb

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review Advances in mouse genetics have made this species particularly useful as a model for human disease. This review will summarize recent advances regarding the pathogenesis of diabetic nephropathy discovered in mice. Recent findings Diabetic nephropathy has been characterized in novel genetic models of murine diabetes including the Akita, Ove26, and ICER-l gamma mice. Mutagenesis resources targeting every gene of the genome and the importance of inbred genetic background are discussed. Summary Through the use of these resources mouse models should provide new insight into the pathogenesis of diabetic nephropathy, and complement human studies and validate the identity of candidate genes contributing to diabetic nephropathy.

引用

页码：227 / 232

页数：6

共 56 条

[1] Advanced glycation endproducts - role in pathology of diabetic complications [J].

Ahmed, N .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2005, 67 (01) :3-21

[2] EFFECT OF GLYCEMIC CONTROL ON EARLY DIABETIC RENAL LESIONS - A 5-YEAR RANDOMIZED CONTROLLED CLINICAL-TRIAL OF INSULIN-DEPENDENT DIABETIC KIDNEY-TRANSPLANT RECIPIENTS [J].

BARBOSA, J ;

STEFFES, MW ;

SUTHERLAND, DER ;

CONNETT, JE ;

RAO, KV ;

MAUER, SM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 272 (08) :600-606

[3] Genetic mapping and ENU mutagenesis [J].

Beier, DR ;

Herron, BJ .

GENETICA, 2004, 122 (01) :65-69

[4] Advanced glycation end products and the kidney [J].

Bohlender, JM ;

Franke, S ;

Stein, G ;

Wolf, G .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2005, 289 (04) :F645-F659

[5] A genome scan for diabetic nephropathy in African Americans [J].

Bowden, DW ;

Colicigno, CJ ;

Langefeld, CD ;

Sale, MM ;

Williams, A ;

Anderson, PJ ;

Rich, SS ;

Freedman, BI .

KIDNEY INTERNATIONAL, 2004, 66 (04) :1517-1526

[6] Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy [J].

Brenner, BM ;

Cooper, ME ;

de Zeeuw, D ;

Keane, WF ;

Mitch, WE ;

Parving, HH ;

Remuzzi, G ;

Snapinn, SM ;

Zhang, ZX ;

Shahinfar, S .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (12) :861-869

[7]

Breyer MD, 2005, J AM SOC NEPHROL, V16, P27, DOI [10.1681/ASN.2004080648, 10.1681/ASN.2009070721]

[8] GLOMERULAR-LESIONS AND URINARY ALBUMIN EXCRETION IN TYPE-I DIABETES WITHOUT OVERT PROTEINURIA [J].

CHAVERS, BM ;

BILOUS, RW ;

ELLIS, EN ;

STEFFES, MW ;

MAUER, SM .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (15) :966-970

[9] Dual blockade of the renin-angiotensin system: The ultimate treatment for renal protection? [J].

Codreanu, I ;

Perico, N ;

Remuzzi, G .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 :S34-S38

[10] N-ethyl-N-nitrosourea mutagenesis:: Boarding the mouse mutant express [J].

Cordes, SP .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2005, 69 (03) :426-+

← 1 2 3 4 5 6 →