Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia

被引:88
作者
Akopian, Armen N. [1 ]
Ruparel, Nikita B. [2 ]
Jeske, Nathaniel A. [3 ]
Patwardhan, Amol [1 ]
Hargreaves, Kenneth M. [1 ,2 ,4 ]
机构
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Endodont, San Antonio, TX 78229 USA
[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA
[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Oral & Maxillofacial Surg, San Antonio, TX 78229 USA
[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA
关键词
ROOT GANGLION NEURONS; TRIGEMINAL SENSORY NEURONS; DEPENDENT PROTEIN-KINASE; MUSTARD OIL RESPONSES; INTRACELLULAR CALCIUM; VANILLOID RECEPTORS; CAPSAICIN RECEPTOR; TYPE-1; RECEPTORS; CHANNEL TRPA1; PAIN;
D O I
10.1016/j.tips.2008.10.008
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Despite the wealth of information on cannabinoid-induced peripheral anti hyperalgesic and antinociceptive effects in many pain models, the molecular mechanism(s) for these actions remains unknown. Although metabotropic cannabinoid receptors have important roles in many pharmacological actions of cannabinoids, recent studies have led to the recognition of a family of at least five ionotropic cannabinoid receptors (ICRs). The known ICRs are members of the family of transient receptor potential (TRP) channels and include TRPV1, TRPV2, TRPV4, TRPM8 and TRPA1. Cannabinoid activation of ICRs can result in desensitization of the TRPA1 and TRPV1 channel activities, inhibition of nociceptors and anti hyperalgesia and antinociception in certain pain models. Thus, cannabinoids activate both metabotropic and ionotropic mechanisms to produce peripheral analgesic effects. Here, we provide an overview of the pharmacology of TRP channels as ICRS.
引用
收藏
页码:79 / 84
页数:6
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