Cytotoxicity of urushiols isolated from sap of Korean lacquer tree (Rhus vernicifera stokes)

被引：57

作者：

Hong, DH ^{[1
]}

Han, SB ^{[1
]}

Lee, CW ^{[1
]}

Park, SH ^{[1
]}

Jeon, YJ ^{[1
]}

Kim, MJ ^{[1
]}

Kwak, SS ^{[1
]}

Kim, KM ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1999年 / 22卷 / 06期

关键词：

urushiols; cytotoxicity; human cancer cells;

D O I：

10.1007/BF02975339

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Cytotoxicities of four urushiols, congeners isolated from the sap of Korean lacquer tree (Rhus vernicifera Stokes), to 29 human cancer cell lines originated from 9 organs were evaluated. Their values of 50% growth inhibition were below 4 mu g/ml, and showed cell line specific cytotoxicity. The present result is the first report on the cytotoxicity of urushiols suggesting that they would have an anticancer activity to human cancer cells.

引用

页码：638 / 641

页数：4

共 8 条

[1]

Cytotoxicity and electron microscopy of cell death induced by goniothalamin [J].

Ali, AM ;

Mackeen, MM ;

Hamid, M ;

Aun, QB ;

Zauyah, Y ;

Azimahtol, HLP ;

Kawazu, K .

PLANTA MEDICA, 1997, 63 (01) :81-83

[2]

PERFLUORINATED ANALOGS OF POISON-IVY ALLERGENS - SYNTHESIS AND SKIN TOLEROGENIC ACTIVITY IN MICE [J].

FRAGINALS, R ;

SCHAEFFER, M ;

STAMPF, JL ;

BENEZRA, C .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (03) :1024-1027

[3]

KALISH RS, 1990, J IMMUNOL, V145, P3706

[4]

PROCESSING OF URUSHIOL (POISON-IVY) HAPTEN BY BOTH ENDOGENOUS AND EXOGENOUS PATHWAYS FOR PRESENTATION TO T-CELLS IN-VITRO [J].

KALISH, RS ;

WOOD, JA ;

LAPORTE, A .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (05) :2039-2047

[5]

Kim HM, 1996, J PHARMACOL TOXICOL, V36, P163

[6]

Kim M. J., 1997, KOREAN J PLANT RESOU, V10, P227

[7]

IMMUNOLOGICAL STUDIES OF POISONOUS ANACARDIACEAE .1. PRODUCTION OF TOLERANCE AND DESENSITIZATION TO POISON IVY AND OAK URUSHIOLS USING ESTERIFIED URUSHIOL DERIVATIVES IN GUINEA-PIGS [J].

WATSON, ES ;

MURPHY, JC ;

WIRTH, PW ;

WALLER, CW ;

ELSOHLY, MA .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1981, 76 (03) :164-170

[8]

WU L, 1992, CANCER RES, V52, P3029

← 1 →