Mediators of peripheral blood neutrophilia induced by photodynamic therapy of solid tumors

被引：126

作者：

Cecic, I ^{[1
]}

Korbelik, M ^{[1
]}

机构：

[1] British Columbia Canc Res Ctr, Canc Imaging Dept, Vancouver, BC V5Z 1L3, Canada

来源：

CANCER LETTERS | 2002年 / 183卷 / 01期

基金：

加拿大健康研究院;

关键词：

photodynamic therapy; neutrophilia; complement; mouse EMT6 tumor;

D O I：

10.1016/S0304-3835(02)00092-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Photodynamic therapy (PDT) of tumors elicits a strong host immune response and one of its manifestations is a pronounced neutrophilia. By blocking their function prior to Photofrin-based PDT of mouse EMT6 tumors, we have identified multiple mediators whose regulated action is responsible for this neutrophilia. In addition to complement fragments (direct mediators) released as a consequence of PDT-induced complement activation, there are at least a dozen secondary mediators that all arise as a result of complement activity. The latter include cytokines IL-1beta, TNF-alpha, IL-6, IL-10, G-CSF and KC, thromboxane, prostaglandins, leukotrienes, histamine, and coagulation factors. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：43 / 51

页数：9

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