DNA binding ligands with excellent antibiotic potency against drug-resistant Gram-positive bacteria

被引：35

作者：

Bürli, RW ^{[1
]}

Ge, YG ^{[1
]}

White, S ^{[1
]}

Baird, EE ^{[1
]}

Touami, SM ^{[1
]}

Taylor, M ^{[1
]}

Kaizerman, JA ^{[1
]}

Moser, HE ^{[1
]}

机构：

[1] Genesoft Inc, San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(02)00515-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient synthesis of DNA binding molecules consisting of four heterocyclic carboxamide units and various substituents at both termini is described. The minor-groove binding ligands showed excellent activity against a broad range of Gram-positive bacteria; no cross-resistance to known antibacterial drugs was observed. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2591 / 2594

页数：4

共 24 条

[1] BASICITY, LIPOPHILICITY, AND LACK OF RECEPTOR INTERACTION OF N-AMINOALKYLBENZAMIDES AND N-AMINOALKYL-ORTHO-ANISAMIDES AS MODEL COMPOUNDS OF DOPAMINE ANTAGONISTS
ANKER, L
TESTA, B
VANDEWATERBEEMD, H
BORNANDCRAUSAZ, A
THEODOROU, A
JENNER, P
MARSDEN, CD
[J]. HELVETICA CHIMICA ACTA, 1983, 66 (02) : 542 - 556
[2] STRUCTURE + SYNTHESIS OF DISTAMYCIN A
ARCAMONE, F
NICOLELL.V
PENCO, S
OREZZI, P
PIRELLI, A
[J]. NATURE, 1964, 203 (494) : 1064 - +
[3] Total synthesis of distamycin A and 2640 analogues: A solution-phase combinatorial approach to the discovery of new, bioactive DNA binding agents and development of a rapid, high-throughput screen for determining relative DNA binding affinity or DNA binding sequence selectivity
Boger, DL
Fink, BE
Hedrick, MP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (27) : 6382 - 6394
[4] BROSIUS J, 1985, J BIOL CHEM, V260, P3539
[5] New directions in antibacterial research
Chu, DTW
Plattner, JJ
Katz, L
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (20) : 3853 - 3874
[6] CONTROL SITE LOCATION AND TRANSCRIPTIONAL REGULATION IN ESCHERICHIA-COLI
COLLADOVIDES, J
MAGASANIK, B
GRALLA, JD
[J]. MICROBIOLOGICAL REVIEWS, 1991, 55 (03) : 371 - 394
[7] Molecular recognition of DNA by small molecules
Dervan, PB
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (09) : 2215 - 2235
[8] Minor groove DNA binders as antimicrobial agents.: 1.: Pyrrole tetraamides are potent antibacterials against vancomycin resistant Enteroccoci and methicillin resistant Staphylococcus aureus
Dyatkina, NB
Roberts, CD
Keicher, JD
Dai, YQ
Nadherny, JP
Zhang, WT
Schmitz, U
Kongpachith, A
Fung, K
Novikov, AA
Lou, L
Velligan, M
Khorlin, AA
Chen, MS
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (04) : 805 - 817
[9] GROSSMAN R, 1992, EARTH ISL J, V7, P2
[10] ANALYSIS OF ESCHERICHIA-COLI PROMOTER SEQUENCES
HARLEY, CB
REYNOLDS, RP
[J]. NUCLEIC ACIDS RESEARCH, 1987, 15 (05) : 2343 - 2361

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