Plasticity of CD4+ T Cell Lineage Differentiation

被引:1253
作者
Zhou, Liang [1 ,2 ]
Chong, Mark M. W. [1 ]
Littman, Dan R. [1 ,2 ]
机构
[1] NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
[2] NYU, Sch Med, Howard Hughes Med Inst, New York, NY 10016 USA
关键词
TRANSCRIPTION FACTOR FOXP3; ROR-GAMMA-T; FOLLICULAR-HELPER-CELLS; TGF-BETA; RETINOIC-ACID; CUTTING EDGE; DNA METHYLATION; GENE-EXPRESSION; TH17; CELLS; AUTOIMMUNE ENCEPHALOMYELITIS;
D O I
10.1016/j.immuni.2009.05.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The differentiation of naive CD4(+) T cells into lineages with distinct effector functions has been considered to be an irreversible event. T helper type 1 (Th1) cells stably express IFN-gamma, whereas Th2 cells express IL-4. The discovery and investigation of two other CD4(+) T cell subsets, induced regulatory T (iTreg) cells and Th17 cells, has led to a rethinking of the notion that helper T cell subsets represent irreversibly differentiated endpoints. Accumulating evidence suggests that CD4(+) T cells, particularly iTreg and Th17 cells, are more plastic than previously appreciated. It appears that expression of Foxp3 by iTreg cells or IL-17 by Th17 cells may not be stable and that there is a great degree of flexibility in their differentiation options. Here, we will discuss recent findings that demonstrate the plasticity of CD4(+) T cell differentiation and the biological implications of this flexibility.
引用
收藏
页码:646 / 655
页数:10
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