The P domain of the P0 protein of Plasmodium falciparum protects against challenge with malaria parasites

被引：36

作者：

Rajeshwari, K ^{[1
]}

Patel, K ^{[1
]}

Nambeesan, S ^{[1
]}

Mehta, M ^{[1
]}

Sehgal, A ^{[1
]}

Chakraborty, T ^{[1
]}

Sharma, S ^{[1
]}

机构：

[1] Tata Inst Fundamental Res, Dept Biol Sci, Bombay 400005, Maharashtra, India

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 09期

关键词：

D O I：

10.1128/IAI.72.9.5515-5521.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monoclonal antibodies (MAbs) specific for the P domain of the Plasmodium falciparum PO phosphoriboprotein (PfP0) blocked the invasion of RBCs by P.falciparum. Vaccination with this P-domain peptide protected mice upon malaria parasite challenge. The absolute specificity of the MAbs and the PfP0 P peptide makes them potential protective malaria reagents.

引用

页码：5515 / 5521

页数：7

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