Antral glutathione concentration and glutathione S-transferase activity in patients with and without Helicobacter pylori

被引:47
作者
Verhulst, ML [1 ]
Van Oijen, AHAM [1 ]
Roelofs, HMJ [1 ]
Peters, WHM [1 ]
Jansen, JBMJ [1 ]
机构
[1] Univ Nijmegen Hosp, Dept Gastroenterol & Hepatol, NL-6500 HB Nijmegen, Netherlands
关键词
Helicobacter pylori; glutathione; glutathione S-transferase;
D O I
10.1023/A:1005426130826
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Previously we demonstrated an inverse relation between cancer of the gastrointestinal tract and glutathione S-transferase activity of the gastrointestinal mucosa. Chronic infection with Pi. pylori has been associated with an increased risk of gastric cancer. The aim of this study was to investigate the levels of glutathione and glutathione S-transferase activity in H. pylori-infected and noninfected antral mucosa. Glutathione and glutathione S-transferases were measured in antral biopsies of patients with nonulcer dyspepsia without Pi pylori infection (A), with prior H, pylori infection who became ii pylori negative after eradication therapy (B) and with proven ii pylori infection (C), Glutathione concentration and glutathione S-transferase activity in group A were 31.0 (range 6.0-59.6) nmol/mg protein and 810 (range 165-1312) nmol/min/mg protein, in group B 27.0 (range 5.0-53.8) nmol/mg protein and 745 (range 403-1199) nmol/min/mg protein, and in group C 18.5 (range 1.6-55.8) nmol/mg protein and 572 (range 144-1047) nmol/min/mg protein, respectively. The glutathione and glutathione S-transferase values were significantly lower in patients infected with H. pylori than in patients who were H. pylori negative.
引用
收藏
页码:629 / 632
页数:4
相关论文
共 11 条
[1]  
Asaka M, 1996, Helicobacter, V1, P52, DOI 10.1111/j.1523-5378.1996.tb00008.x
[2]   IS GASTRIC-CARCINOMA AN INFECTIOUS-DISEASE [J].
CORREA, P .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (16) :1170-1171
[3]  
FORMAN D, 1993, LANCET, V341, P1359
[4]   The glutathione S-Transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance [J].
Hayes, JD ;
Pulford, DJ .
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1995, 30 (06) :445-600
[5]  
IARC, 1994, IARC MON EV CARC RIS, P177
[6]   LONG-TERM SEQUELAE OF HELICOBACTER-PYLORI GASTRITIS [J].
KUIPERS, EJ ;
UYTERLINDE, AM ;
PENA, AS ;
ROOSENDAAL, R ;
PALS, G ;
NELIS, GF ;
FESTEN, HPM ;
MEUWISSEN, SGM .
LANCET, 1995, 345 (8964) :1525-1528
[7]  
NIJHOFF WA, 1993, INT J ONCOL, V3, P1131
[8]   HELICOBACTER-PYLORI INFECTION AND THE RISK OF GASTRIC-CARCINOMA [J].
PARSONNET, J ;
FRIEDMAN, GD ;
VANDERSTEEN, DP ;
CHANG, Y ;
VOGELMAN, JH ;
ORENTREICH, N ;
SIBLEY, RK .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (16) :1127-1131
[9]   GLUTATHIONE AND GLUTATHIONE S-TRANSFERASES IN BARRETT EPITHELIUM [J].
PETERS, WHM ;
ROELOFS, HMJ ;
HECTORS, MPC ;
NAGENGAST, FM ;
JANSEN, JBMJ .
BRITISH JOURNAL OF CANCER, 1993, 67 (06) :1413-1417
[10]   EXPRESSION OF GLUTATHIONE S-TRANSFERASES IN NORMAL GASTRIC-MUCOSA AND IN GASTRIC TUMORS [J].
PETERS, WHM ;
WORMSKAMP, NGM ;
THIES, E .
CARCINOGENESIS, 1990, 11 (09) :1593-1596