Expression of CD27 on murine hematopoietic stem and progenitor cells

被引：84

作者：

Wiesmann, A

Phillips, RL

Mojica, M

Pierce, LJ

Searles, AE

Spangrude, GJ

Lemischka, I ^{[1
]}

机构：

[1] Univ Utah, Dept Oncol Sci, Salt Lake City, UT 84132 USA

[2] Univ Utah, Dept Human Genet, Salt Lake City, UT 84132 USA

[3] Univ Utah, Dept Pathol, Salt Lake City, UT 84132 USA

[4] Univ Utah, Dept Med, Div Hematol, Salt Lake City, UT 84132 USA

[5] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

IMMUNITY | 2000年 / 12卷 / 02期

关键词：

D O I：

10.1016/S1074-7613(00)80172-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hematopoietic stem cells (HSC) are defined by self-renewal and multilineage differentiation potentials. In order to uncover the genetic program of HSC, we utilized high-density arrays to compare gene expression in highly purified mouse HSC and their mature progeny. One molecule specifically expressed in immature cells is CD27, a member of the TNF receptor family previously shown to play roles in lymphoid proliferation, differentiation, and apoptosis. We show here that the CD27 protein is expressed by about 90% of cells in a purified HSC population. Interestingly, the CD27(pos) cells are enriched for cells with short-term hematopoietic activities (colony forming potential in vivo and in vitro), while the minority CD27(neg) population is more effective in clonal long-term transplantation.

引用

页码：193 / 199

页数：7

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