Toward Alzheimer therapies based on genetic knowledge

被引：25

作者：

Hardy, J ^{[1
]}

机构：

[1] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2004年 / 55卷

关键词：

animal models; cholesterol; anti-inflammatory; immunotherapy; amyloid;

D O I：

10.1146/annurev.med.55.091902.103607

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Genetic analysis has allowed the dissection of the pathogenic pathway that leads to Alzheimer's disease. It has also been integral to the development of earlier and more accurate diagnostic practices. This analysis has identified many potential therapeutic targets, and clinical trials aimed at these targets are now under way. If these approaches are successful, it will be a spectacular validation of genetic-knowledge-based treatment strategies; if they are not, researchers will need to re-evaluate this approach toward understanding and developing strategies for treating complex diseases.

引用

页码：15 / 25

页数：13

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