Tight relationships between B lymphocytes and the skeletal system

被引：60

作者：

Manilay, Jennifer O. ^{[1
,2
]}

Zouali, Moncef ^{[3
,4
]}

机构：

[1] Univ Calif Merced, Sch Nat Sci, Mol & Cell Biol Unit, Merced, CA 95343 USA

[2] Univ Calif Merced, Sch Nat Sci, Quantitat & Syst Biol Grad Grp, Merced, CA 95343 USA

[3] INSERM, UMR S 606 1132, F-75475 Paris, France

[4] Univ Paris Diderot, Sorbonne Paris Cite, F-75475 Paris, France

来源：

TRENDS IN MOLECULAR MEDICINE | 2014年 / 20卷 / 07期

关键词：

osteoimmunology; B lymphocyte; osteoclast; osteoblast; osteocyte; MESENCHYMAL STEM-CELLS; NF-KAPPA-B; BONE-MARROW; CRE RECOMBINASE; TRANSGENIC MICE; OSTEOCLAST DIFFERENTIATION; OSTEOPROTEGERIN; EXPRESSION; LYMPHOPOIESIS; REGULATOR;

D O I：

10.1016/j.molmed.2014.03.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Mounting evidence indicates that the immune system and the skeletal system share several regulatory nodes. B lymphocytes, which play key roles in immune homeostasis, are uniquely endowed with osteointeractive properties. From their early development to the plasma cell stage, they are in close proximity with the skeletal system and produce factors important for bone maintenance. Not surprisingly, perturbation of B lymphopoiesis affects bone mass. Reciprocally, inactivation of bone cell functions results in B cell development blocks. This new understanding is refining our insights into the pathogenesis of several diseases such as periodontitis and rheumatoid arthritis.

引用

页码：405 / 412

页数：8

共 84 条

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