Comparative Effects of Hispidulin, Genistein, and Icariin with Estrogen on Bone Tissue in Ovariectomized Rats

被引：41

作者：

Yang, Lijuan ^{[1
]}

Yu, Zixu ^{[1
]}

Qu, Haili ^{[1
]}

Li, Minmin ^{[1
]}

机构：

[1] Shandong Univ, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2014年 / 70卷 / 01期

关键词：

Genistein; Icariin; Hispidulin; Osteoporosis; POSTMENOPAUSAL WOMEN; DOUBLE-BLIND; PHYTOESTROGEN GENISTEIN; VAGINAL EPITHELIUM; HOT FLUSHES; OSTEOPOROSIS; TRIAL; MINERALIZATION; ENDOMETRIUM; ACTIVATION;

D O I：

10.1007/s12013-014-9945-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Icariin, Genistein, and Hispidulin have been proven to have estrogen-like and antiosteoporotic activity and can be potentially used for the treatment of osteoporosis. The present study found that Icariin, Genistein, and Hispidulin treatments, emulating estrogen, significantly contributed to bone density. Comparative effects of Icariin, Genistein, and Hispidulin with estrogen on in ovariectomized rats were investigated. Our results showed that genistein was found to have superior bone protective effects against osteoporosis among genistein, Icariin, and Hispidulin.

引用

页码：485 / 490

页数：6

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