Gender impact on first trimester markers in Down syndrome screening

被引：28

作者：

Larsen, SO

Wojdemann, KR

Shalmi, AC

Sundberg, K

Christiansen, M

Tabor, A

机构：

[1] Statens Serum Inst, Dept Clin Biochem, DK-2300 Copenhagen S, Denmark

[2] Hvidovre Univ Hosp, Dept Obstet & Gynecol, DK-2650 Hvidovre, Denmark

[3] Rigshosp, Dept Ultrasound & Obstet, DK-2100 Copenhagen, Denmark

来源：

PRENATAL DIAGNOSIS | 2002年 / 22卷 / 13期

关键词：

Down syndrome; screening; gender impact; first trimester;

D O I：

10.1002/pd.493

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The influence of fetal gender on the level in the first trimester of the serological markers alpha-fetoprotein (AFP), pregnancy-associated plasma protein-A (PAPP-A) and free beta human chorionic gonadotropin (betahCG) and on nuchal translucency is described for 2637 singleton pregnancies with normal outcome. Mean log MoM values for pregnancies with female and male fetuses were calculated using regression of log marker values on gestational age expressed as crown rump length and on maternal weight. A pronounced gender impact was found for free betahCG, being 16% higher for female than for male fetuses. Copyright (C) 2002 John Wiley Sons. Ltd.

引用

页码：1207 / 1208

页数：2

共 8 条

[1]

de Graaf IM, 2000, PRENATAL DIAG, V20, P186, DOI 10.1002/(SICI)1097-0223(200003)20:3<186::AID-PD776>3.0.CO

[2]

2-A

[3] The effect of fetal gender on nuchal translucency at 10-14 weeks of gestation [J].