Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin

被引:356
作者
Isbrucker, R. A. [1 ]
Burdock, G. A. [1 ]
机构
[1] Burdock Grp, Washington, DC 20006 USA
关键词
licorice; glycyrrhizin; toxicity; GRAS; additive; Burdock; food; flavor; FEMA; generally recognized as safe; JECFA; food additive; sweetener; 11 beta-hydroxysteroid dehydrogenase; enzyme; cortisol; hypermineralocorticoid; teratogen; mutagen; cytotoxicity; carcinogenicity; safetyl;
D O I
10.1016/j.yrtph.2006.06.002
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
Licorice (or 'liquorice') is a plant of ancient origin and steeped in history. Licorice extracts and its principle component, glycyrrhizin, have extensive use in foods, tobacco and in both traditional and herbal medicine. As a result, there is a high level of use of licorice and glycyrrhizin in the US with an estimated consumption of 0.027-3.6mg glycyrrhizin/kg/day. Both products have been approved for use in foods by most national and supranational regulatory agencies. Biochemical studies indicate that glycyrrhizinates inhibit 11 beta-hydroxysteroid dehydrogenase, the enzyme responsible for inactivating cortisol. As a result, the continuous, high level exposure to glycyrrhizin compounds can produce hypermineralocorticoid-like effects in both animals and humans. These effects are reversible upon withdrawal of licorice or glycyrrhizin. Other in vivo and clinical studies have reported beneficial effects of both licorice and glycyrrhizin consumption including anti-ulcer, anti-viral, and hepatoprotective responses. Various genotoxic studies have indicated that glycyrrhizin is neither teratogenic nor mutagenic, and may possess anti-genotoxic properties under certain conditions. The pharmacokinetics of glycyrrhizin have been described and show that its bioavailability is reduced when consumed as licorice; this has hampered attempts to establish clear dose-effect levels in animals and humans. Based on the in vivo and clinical evidence, we propose an acceptable daily intake of 0.015-0.229 mg glycyrrhizin/kg body weight/day. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:167 / 192
页数:26
相关论文
共 157 条
[1]   EFFECTS OF GLYCYRRHIZIN AND GLYCYRRHETINIC ACID ON GROWTH AND MELANOGENESIS IN CULTURED B-16 MELANOMA-CELLS [J].
ABE, H ;
OHYA, N ;
YAMAMOTO, KF ;
SHIBUYA, T ;
ARICHI, S ;
ODASHIMA, S .
EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1987, 23 (10) :1549-&
[2]   INTERFERON INDUCTION BY GLYCYRRHIZIN AND GLYCYRRHETINIC ACID IN MICE [J].
ABE, N ;
EBINA, T ;
ISHIDA, N .
MICROBIOLOGY AND IMMUNOLOGY, 1982, 26 (06) :535-539
[3]  
Addae-Mensah I, 2005, WHO TECH REP SER, V929, P1
[4]   METABOLISM OF GLYCYRRHETIC ACID BY RAT-LIVER MICROSOMES .3. MALE-SPECIFIC GLYCYRRHETINATE DEHYDROGENASE [J].
AKAO, T ;
AKAO, T ;
AOYAMA, M ;
KOBASHI, K .
BIOCHEMICAL PHARMACOLOGY, 1991, 42 (01) :103-107
[5]   INHIBITORY EFFECTS OF GLYCYRRHETIC ACID-DERIVATIVES ON 11-BETA-HYDROXYSTEROID AND 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES OF RAT-LIVER [J].
AKAO, T ;
TERASAWA, T ;
HIAI, S ;
KOBASHI, K .
CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (11) :3021-3024
[6]   INTESTINAL BACTERIAL HYDROLYSIS IS INDISPENSABLE TO ABSORPTION OF 18-BETA-GLYCYRRHETIC ACID AFTER ORAL-ADMINISTRATION OF GLYCYRRHIZIN IN RATS [J].
AKAO, T ;
HAYASHI, T ;
KOBASHI, K ;
KANAOKA, M ;
KATO, H ;
KOBAYASHI, M ;
TAKEDA, S ;
OYAMA, T .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1994, 46 (02) :135-137
[7]   METABOLISM OF GLYCYRRHETIC ACID BY RAT-LIVER MICROSOMES - GLYCYRRHETINATE DEHYDROGENASE [J].
AKAO, T ;
AKAO, T ;
KOBASHI, K .
BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1042 (02) :241-246
[8]   Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats [J].
Al-Qarawi, AA ;
Abdel-Rahman, HA ;
Ali, BH ;
El Mougy, SA .
FOOD AND CHEMICAL TOXICOLOGY, 2002, 40 (10) :1525-1527
[9]  
[Anonymous], PHARM CHINESE HERBS
[10]  
[Anonymous], HERBS BOT TEAS