Risk of pancreatic and periampullar cancer following cholecystectomy - A population-based cohort study

被引:42
作者
Ekbom, A
Yuen, J
Karlsson, BM
McLaughlin, JK
Adami, HO
机构
[1] UNIV UPPSALA HOSP,DEPT SURG,S-75185 UPPSALA,SWEDEN
[2] NCI,DIV CANC ETIOL,EPIDEMIOL & BIOSTAT PROGRAM,BETHESDA,MD 20892
[3] HARVARD UNIV,SCH PUBL HLTH,DEPT EPIDEMIOL,BOSTON,MA 02115
关键词
cholecystectomy; pancreatic cancer periampullar cancer; epidemiology;
D O I
10.1007/BF02093833
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
An increased risk of pancreatic cancer following cholecystectomy has been reported in some studies but not in others. In order to settle this question, a population-based cohort consisting of 62,615 patients who had undergone cholecystectomy was followed up for the occurrence of pancreatic and periampullar cancer up to 23 years. After excluding the first year after operation, there were 261 pancreatic cancers vs 216.8 expected [standardized incidence ratio (SIR) = 1.20; 95% confidence interval (CI) = 1.06-1.37]; and 11 periampullar cancers vs 7.2 expected (SIR = 1.52; 95% CI = 0.76-2.72). The increased risk of pancreatic cancer was most prominent up to four years after operation, but was also significantly increased 15 years or more after operation (SIR = 1.35; 95% CI = 1.00-1.78). We conclude that there is a modest excess risk of pancreatic and periampullar cancer following cholecystectomy, most prominent up to four pears after operation, but that also exists 15 years or more after operation.
引用
收藏
页码:387 / 391
页数:5
相关论文
共 27 条
[1]  
BAILAR JC, 1964, BIOMETRICS, V20, P639
[2]  
BARON JA, 1990, SMOKING HORMONE RELA, P103
[3]  
BELL ET, 1957, AM J PATHOL, V33, P499
[4]   EXPERIMENTAL PANCREATIC-CANCER IN THE SYRIAN-HAMSTER - EFFECT OF CHOLECYSTECTOMY [J].
CHESTER, JF ;
NORRIS, MA ;
LEVER, JV ;
TURNBULL, AR ;
BRITTON, DC .
DIGESTION, 1989, 44 (01) :36-40
[5]   PANCREATIC-CANCER, ALCOHOL, DIABETES-MELLITUS AND GALLBLADDER-DISEASE [J].
CUZICK, J ;
BABIKER, AG .
INTERNATIONAL JOURNAL OF CANCER, 1989, 43 (03) :415-421
[6]   DIABETES-MELLITUS AS A RISK FACTOR FOR PANCREATIC-CANCER - A METAANALYSIS [J].
EVERHART, J ;
WRIGHT, D .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (20) :1605-1609
[7]   RISK OF PANCREATIC-CANCER IN RELATION TO MEDICAL HISTORY AND THE USE OF TOBACCO, ALCOHOL AND COFFEE [J].
FARROW, DC ;
DAVIS, S .
INTERNATIONAL JOURNAL OF CANCER, 1990, 45 (05) :816-820
[8]  
GOLD EB, 1985, CANCER-AM CANCER SOC, V55, P460, DOI 10.1002/1097-0142(19850115)55:2<460::AID-CNCR2820550229>3.0.CO
[9]  
2-V
[10]   A CASE-CONTROL STUDY OF PANCREATIC-CARCINOMA [J].
HAINES, AP ;
MOSS, AR ;
WHITTEMORE, A ;
QUIVEY, J .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1982, 103 (01) :93-97