Inflammation in Coronary Artery Disease

被引：112

作者：

Christodoulidis, Georgios ^{[1
]}

Vittorio, Timothy J. ^{[2
]}

Fudim, Marat ^{[3
]}

Lerakis, Stamatios ^{[4
]}

Kosmas, Constantine E. ^{[5
]}

机构：

[1] Winthrop Univ Hosp, Dept Internal Med, Mineola, NY 11501 USA

[2] St Francis Hosp, Ctr Adv Cardiac Therapeut, Div Cardiol, Ctr Heart, Roslyn, NY USA

[3] Vanderbilt Univ, Sch Med, Dept Internal Med, Nashville, TN 37212 USA

[4] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA

[5] Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

来源：

CARDIOLOGY IN REVIEW | 2014年 / 22卷 / 06期

关键词：

acute-phase response; atherosclerosis; chemokines; cytokines; inflammatory markers; pathogenesis; proliferation; C-REACTIVE PROTEIN; MONOCYTE CHEMOATTRACTANT PROTEIN-1; LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; NECROSIS-FACTOR-ALPHA; E-KNOCKOUT MICE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RECEPTOR-DEFICIENT MICE; AMERICAN-HEART-ASSOCIATION; 1ST CARDIOVASCULAR EVENTS;

D O I：

10.1097/CRD.0000000000000006

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Coronary artery disease (CAD) is the leading cause of death in the United States. Although CAD was formerly considered a lipid accumulation-mediated disease, it has now been clearly shown to involve an ongoing inflammatory response. Advances in basic science research have established the crucial role of inflammation in mediating all stages of CAD. Today, there is convincing evidence that multiple interrelated immune mechanisms interact with metabolic risk factors to initiate, promote, and ultimately activate lesions in the coronary arteries. This review aims to provide current evidence pertaining to the role of inflammation in the pathogenesis of CAD and discusses the impact of inflammatory markers and their modification on clinical outcomes.

引用

页码：279 / 288

页数：10

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