The ARF/p53 pathway

被引：543

作者：

Sherr, CJ ^{[1
]}

Weber, JD ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Howard Hughes Med Inst, Dept Tumor Cell Biol, Memphis, TN 38105 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(99)00038-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53, ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.

引用

页码：94 / 99

页数：6

共 49 条

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