Genetic analysis of African populations: Human evolution and complex disease

被引：268

作者：

Tishkoff, SA ^{[1
]}

Williams, SM

机构：

[1] Univ Maryland, Dept Biol, College Pk, MD 20742 USA

[2] Meharry Med Coll, Dept Microbiol, Nashville, TN 37208 USA

[3] Vanderbilt Univ, Med Ctr, Div Cardiovasc Med, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Med Ctr, Program Human Genet, Nashville, TN 37232 USA

来源：

NATURE REVIEWS GENETICS | 2002年 / 3卷 / 08期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg865

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Africa is one of the most ethnically and genetically diverse regions of the world. It is thought to be the ancestral homeland of all modern humans, and is the homeland of millions of people of the recent African diaspora. Because of the central role of African populations in human history, characterizing their patterns of genetic diversity and linkage disequilibrium is crucial for reconstructing human evolution and for understanding the genetic basis of complex diseases.

引用

页码：611 / 621

页数：11

共 128 条

[1] A highly variable segment of human subterminal 16p reveals a history of population growth for modern humans outside Africa [J].