Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) With a History of Coinfection With Human Immunodeficiency Virus Type 1 and Hepatitis C Virus

被引：100

作者：

Zhao, Juanjuan ^{[1
]}

Liao, Xuejiao ^{[1
]}

Wang, Haiyan ^{[1
]}

Wei, Lanlan ^{[1
]}

Xing, Mingzhao ^{[2
]}

Liu, Lei ^{[1
,2
]}

Zhang, Zheng ^{[1
,2
]}

机构：

[1] Shenzhen Third Peoples Hosp, Natl Clin Res Ctr Infect Dis, Inst Hepatol, Shenzhen, Guangdong, Peoples R China

[2] Southern Univ Sci & Technol, Sch Med, Shenzhen, Guangdong, Peoples R China

来源：

CLINICAL INFECTIOUS DISEASES | 2020年 / 71卷 / 16期

关键词：

SARS-CoV-2; COVID-19; HIV-1; HCV; antibody;

D O I：

10.1093/cid/ciaa408

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The effect of host immune status on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. Here, we report the first case of coronavirus disease 2019 (COVID-19) with human immunodeficiency virus type 1 (HIV-1)/hepatitis C virus coinfection, who showed a persistently negative SARS-CoV-2 RNA test but delayed antibody response in the plasma. This case highlights the influence of HIV-1-induced immune dysfunction on early SARS-CoV-2 clearance.

引用

页码：2233 / 2235

页数：3

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