Telomere Aggregates in Hepatitis C Patients

被引：9

作者：

Amiel, A. ^{[1
,2
]}

Fejgin, M. D. ^{[1
,3
]}

Goldberg-Bittman, L. ^{[1
,2
]}

Sharoni, R. ^{[1
,3
]}

Hadary, R. ^{[3
,4
]}

Kitay-Cohen, Y. ^{[3
,4
]}

机构：

[1] Meir Hosp, Genet Inst, Kefar Sava, Israel

[2] Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel

[3] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

[4] Meir Hosp, Liver Unit, Kefar Sava, Israel

来源：

CANCER INVESTIGATION | 2009年 / 27卷 / 06期

关键词：

Cancer genetics; Detection; Diagnosis; Liver and biliary system; SUSTAINED VIROLOGICAL RESPONSE; HEPATOCELLULAR-CARCINOMA; RANDOM ANEUPLOIDY; IMMORTAL CELLS; BROKEN ENDS; CANCER; CHROMOSOMES; LYMPHOMA; CRYOGLOBULINEMIA; REARRANGEMENTS;

D O I：

10.1080/07357900802350806

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Telomeres of tumor nuclei tend to form aggregates (TA). The aim of this study was to estimate the TA formation in leukocytes of patients with chronic hepatitis C (HCV) which is considered to be premalignant disease, in patients of HCV who eradicated the virus. PNA Telomere kit (Dako) was used to evaluate the TA formation with the utilization of 2D fluorescence microscopy. A higher rate of TA was found in both HCV groups as compared to controls. Our results indicate that HCV patients have some of the components that create the cascade of events leading to malignancies.

引用

页码：650 / 654

页数：5

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