Gene-environment interdependence

被引：157

作者：

Rutter, Michael ^{[1
]}

机构：

[1] Inst Psychiat, SGDP Ctr, London SE5 8AF, England

来源：

DEVELOPMENTAL SCIENCE | 2007年 / 10卷 / 01期

关键词：

SEROTONIN TRANSPORTER; INDIVIDUAL-DIFFERENCES; MATERNAL-BEHAVIOR; ALZHEIMER-DISEASE; APOLIPOPROTEIN-E; HUMAN AMYGDALA; POLYMORPHISM; GENOTYPE; CHILDREN; MODEL;

D O I：

10.1111/j.1467-7687.2007.00557.x

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Behavioural genetics was initially concerned with partitioning population variance into that due to genetics and that due to environmental influences. The implication was that the two were separate and it was assumed that gene-environment interactions were usually of so little importance that they could safely be ignored. Theoretical considerations suggested that that was unlikely to be true and empirical findings are now accumulating on the demonstrated and replicated biological interactions between identified common single genetic variants and the operation of environmentally mediated risks. The paper outlines the evidence and considers why it is changing concepts in ways that matter.

引用

页码：12 / 18

页数：7

共 42 条

[1] [Anonymous], 2006, GENES BEHAV
[2] Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques
Barr, CS
Newman, TK
Shannon, C
Parker, C
Dvoskin, RL
Becker, ML
Schwandt, M
Champoux, M
Lesch, KP
Goldman, D
Suomi, SJ
Higley, JD
[J]. BIOLOGICAL PSYCHIATRY, 2004, 55 (07) : 733 - 738
[3] Developmental plasticity and human health
Bateson, P
Barker, D
Clutton-Brock, T
Deb, D
D'Udine, B
Foley, RA
Gluckman, P
Godfrey, K
Kirkwood, T
Lahr, MM
McNamara, J
Metcalfe, NB
Monaghan, P
Spencer, HG
Sultan, SE
[J]. NATURE, 2004, 430 (6998) : 419 - 421
[4] Early experience and serotonin transporter gene variation interact to influence primate CNS function
Bennett, AJ
Lesch, KP
Heils, A
Long, JC
Lorenz, JG
Shoaf, SE
Champoux, M
Suomi, SJ
Linnoila, MV
Higley, JD
[J]. MOLECULAR PSYCHIATRY, 2002, 7 (01) : 118 - 122
[5] The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care
Cameron, NM
Champagne, FA
Fish, CPEW
Ozaki-Kuroda, K
Meaney, MJ
[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2005, 29 (4-5) : 843 - 865
[6] Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction
Caspi, A
Moffitt, TE
Cannon, M
McClay, J
Murray, R
Harrington, H
Taylor, A
Arseneault, L
Williams, B
Braithwaite, A
Poulton, R
Craig, IW
[J]. BIOLOGICAL PSYCHIATRY, 2005, 57 (10) : 1117 - 1127
[7] Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
Caspi, A
Sugden, K
Moffitt, TE
Taylor, A
Craig, IW
Harrington, H
McClay, J
Mill, J
Martin, J
Braithwaite, A
Poulton, R
[J]. SCIENCE, 2003, 301 (5631) : 386 - 389
[8] Role of genotype in the cycle of violence in maltreated children
Caspi, A
McClay, J
Moffitt, TE
Mill, J
Martin, J
Craig, IW
Taylor, A
Poulton, R
[J]. SCIENCE, 2002, 297 (5582) : 851 - 854
[9] Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat
Champagne, FA
Chretien, P
Stevenson, CW
Zhang, TY
Gratton, A
Meaney, MJ
[J]. JOURNAL OF NEUROSCIENCE, 2004, 24 (17) : 4113 - 4123
[10] Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates
Champoux, M
Bennett, A
Shannon, C
Higley, JD
Lesch, KP
Suomi, SJ
[J]. MOLECULAR PSYCHIATRY, 2002, 7 (10) : 1058 - 1063

← 1 2 3 4 5 →