From structure to function: Approaches and limitations

被引：167

作者：

Thornton, JM

Todd, AE

Milburn, D

Borkakoti, N

Orengo, CA

机构：

[1] Univ Coll, Dept Biochem & Mol Biol, London WC1 6BT, England

[2] Univ London Birkbeck Coll, Dept Crystallog, London WC1 7HX, England

[3] Roche Discovery Welwyn, Welwyn Garden City AL7 3AY, Herts, England

来源：

NATURE STRUCTURAL BIOLOGY | 2000年 / 7卷 / Suppl 11期

关键词：

D O I：

10.1038/80784

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review presents a summary of current approaches to extract functional information from structural data on proteins and their complexes. While structural homologs may reveal possible biochemical functions (which may be hidden at the sequence level), elucidating the exact biological role of a protein in vivo will only be possible by including other results, such as data on expression and localization.

引用

页码：991 / 994

页数：4

共 24 条

[1]

Brenner SE, 2000, PROTEIN SCI, V9, P197

[2] The 1.8 Å crystal structure of the ycaC gene product from Escherichia coli reveals an octameric hydrolase of unknown specificity [J].