Chemical protein synthesis

被引：74

作者：

Kochendoerfer, GG ^{[1
]}

Kent, SBH ^{[1
]}

机构：

[1] Gryphon Sci, S San Francisco, CA 94080 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 06期

关键词：

D O I：

10.1016/S1367-5931(99)00024-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the mid-1990s, chemical synthesis has emerged as a powerful technique for the study of structure/function relationships in proteins. During the review period, the applicability of chemical protein synthesis techniques has been significantly broadened by increases in the size of synthetically accessible proteins through two new techniques: solid-phase protein synthesis and expressed protein ligation. Also in the period under review, synthetic access to novel classes of proteins has been established, including metalloproteins with tuned properties and integral membrane proteins.

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页码：665 / 671

页数：7

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