Role of intramitochondrial nitric oxide in rat heart and kidney during hypertension

被引：14

作者：

Aguilera-Aguirre, L

González-Hernández, JC

Pérez-Vázquez, V

Ramírez, J

Clemente-Guerrero, M

Villalobos-Molina, R

Saavedra-Molina, A

机构：

[1] Univ Michoacana San Nicolas Hidalgo, Inst Invest Quim Biol, Morelia 58030, Michoacan, Mexico

[2] IPN, CINVESTAV, Dept Farmacobiol, Sede Sur, DF, Mexico

来源：

MITOCHONDRION | 2002年 / 1卷 / 05期

关键词：

nitric oxide; nitric oxide synthase; hypertension; mitochondria;

D O I：

10.1016/S1567-7249(02)00002-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nitric oxide (NO) is an important reactive molecule in many organisms. A mitochondrial nitric oxide synthase has been described; however, the role of NO in this organelle is not yet fully clear. We tested the effect of intramitochondrial NO on various functions from spontaneously hypertensive rats (SHR) and their normotensive genetic control, Wistar-Kyoto (WKY) rats. While the stimulation of intramitochondrial NOS increased calcium- and phosphate-induced permeability transition pore opening, its inhibition partially prevented it, without affecting membrane potential. Matrix free calcium and the pH decreased with NOS inhibition. Basal [NO] was lower in SHR than in WKY. Our data suggest that intramitochondrial NO plays an important role in mitochondrial regulation during hypertension. (C) 2002 Elsevier Science B.V. and Mitrochondria Research Society. All rights reserved.

引用

页码：413 / 423

页数：11

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