Gymnasterkoreaynes A-F, cytotoxic polyacetylenes from Gymnaster koraiensis

被引：63

作者：

Jung, HJ

Min, BS

Park, JY

Kim, YH

Lee, HK

Bae, KH ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 06期

关键词：

D O I：

10.1021/np0104018

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new polyacetylenes, gymnasterkoreaynes A-F (1-6), were isolated from the roots of Gymnaster koraiensis, together with 2,9,16-heptadecatrien-4,6-diyn-8-ol (7) and 1,9,16-heptadecatriene-4,6-diyn-3,8-diol (8), by bioassay-guided fractionation using the L1210 tumor cell line as a model for cytotoxicity. The structures of compounds 1-6 were established spectroscopically, which included 2D NMR experiments. Gymnasterkoreaynes A-F (1-6) are linear diacetylenes and are structurally related to falcarinol, panaxynol, panaxydiol, and panakytriol. Of the compounds isolated, gymnasterkoreaynes B (2), C (3), F (6), and 1,9,16-heptadecatrien-4,6-diyn-3,8-diol (8) exhibited significant cytotoxicity against L1210 tumor cells with ED50 values of 0.12-3.3 mug/mL.

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页码：897 / 901

页数：5

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