Simulation studies of a helical m-phenylene ethynylene foldamer

被引：30

作者：

Lee, OS ^{[1
]}

Saven, JG ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Makineni Theoret Labs, Philadelphia, PA 19104 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2004年 / 108卷 / 32期

关键词：

D O I：

10.1021/jp048642m

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The folded state of an oligo(m-phenylene ethynylene) foldamer solvated in water is examined using a 30 ns NpT molecular dynamics simulation. The 18-monomer oligomer with methyl ester exterior side groups maintains a helical structure, where turns of the helix are in close contact throughout the simulation. The structure exhibits large fluctuations in both the radius of the interior cylindrical pore and the effective dihedral angle between monomers. The radius fluctuations are correlated with the number of water molecules within the helical pore. The folded state is found to be surprisingly flexible while maintaining a helical structure.

引用

页码：11988 / 11994

页数：7

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