High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma

被引：9

作者：

Green, Michael ^{[2
,3
]}

Gandhi, Maher K. ^{[2
,3
,4
,5
]}

Camilleri, Emily

Marlton, Paula ^{[5
]}

Lea, Rod ^{[6
]}

Griffiths, Lyn ^{[1
,2
,3
]}

机构：

[1] Griffith Univ, Genom Res Ctr, Griffith Inst Hlth & Med Res, PMB Gold Coast Mail Ctr 50, Griffith, Qld 9726, Australia

[2] Griffith Univ, Joint Program, Griffith Med Res Coll, Griffith, Qld 4029, Australia

[3] Queensland Inst Med Res, Brisbane, Qld 4029, Australia

[4] Queensland Inst Med Res, Clin Immunohaematol Lab, Brisbane, Qld 4006, Australia

[5] Princess Alexandra Hosp, Queensland Hlth, Qld 4102, Australia

[6] Inst Environm Sci & Res, Wellington, New Zealand

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 05期

关键词：

Non-Hodgkin's lymphoma; Follicular lymphoma; Diffuse large B-cell lymphoma; BACH2; BCL2; t(14; 18)(q21; q34); B-CELL LYMPHOMA; EXPRESSION;

D O I：

10.1016/j.leukres.2008.09.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large B-cell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

引用

页码：731 / 734

页数：4

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