Itch-scratch responses induced by lysophosphatidic acid in mice

被引：64

作者：

Hashimoto, T ^{[1
]}

Ohata, H ^{[1
]}

Momose, K ^{[1
]}

机构：

[1] Showa Univ, Sch Pharmaceut Sci, Dept Pharmacol, Tokyo 142, Japan

来源：

PHARMACOLOGY | 2004年 / 72卷 / 01期

关键词：

lysophosphatidic acid; Rho-associated protein kinase; itch-scratch response; histamine; capsaicin; mice; lysophosphatidic acid induced itch-scratch response;

D O I：

10.1159/000078632

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present investigation was conducted in order to determine whether lysophosphatidic acid (LPA) induces itch-scratch responses (ISRs) in mice. Intradermal administration of LPA induces ISRs; furthermore, the time course for LPA-induced ISRs was similar to that for histamine-induced responses. Comparative study of the pruritogenic activity revealed that histamine possessed a potent effect characterized by a dose-response relationship; however, prostaglandin D-2 failed to induce this response. Pretreatment with ketotifen, a histamine H-1 receptor antagonist, and capsaicin inhibited LPA-induced ISRs. Additionally, LPA-induced ISRs were abolished by Y-27632, an inhibitor of Rho-associated protein kinase (ROCK). These findings suggest that LPA-induced ISRs are attributable to histamine- and substance-P-mediated pathways. Moreover, the Rho/ROCK-mediated pathway may be involved. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：51 / 56

页数：6

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