Mast-cell responses to pathogens

被引：645

作者：

Marshall, JS

机构：

[1] Dalhousie Univ, Dept Microbiol & Immunol, Dalhousie Inflammat Grp, Halifax, NS B3H 1X5, Canada

[2] Dalhousie Univ, Dept Pathol, Dalhousie Inflammat Grp, Halifax, NS B3H 1X5, Canada

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 10期

关键词：

D O I：

10.1038/nri1460

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mast cells have mainly been studied in the setting of allergic disease, but the importance of mast cells for host defence against several pathogens has now been well established. The location of mast cells, which are found closely associated with blood vessels, allows them to have a crucial sentinel role in host defence. The mast cell has a unique `armamentarium' of receptor systems and mediators for responding to pathogen-associated signals. Studies of this intriguing immune-effector cell provide important insights into the complex mechanisms by which appropriate innate and acquired immune responses are initiated.

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页码：787 / 799

页数：13

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