Mucositis: from febrile neutropenia to febrile mucositis

被引：34

作者：

Blijlevens, Nicole M. A. ^{[1
]}

Logan, Richard M. ^{[2
]}

Netea, Mihai G. ^{[3
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Haematol, NL-6500 HB Nijmegen, Netherlands

[2] Univ Adelaide, Fac Hlth Sci, Sch Dent, Discipline Oral Pathol, Adelaide, SA 5005, Australia

[3] Radboud Univ Nijmegen, Med Ctr, Dept Med, NL-6500 HB Nijmegen, Netherlands

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2009年 / 63卷

关键词：

mucosal barrier injury; innate immunity; inflammation; cancer treatment; infections; CLINICAL-PRACTICE GUIDELINES; ACUTE INFLAMMATORY RESPONSE; ALIMENTARY-TRACT MUCOSITIS; ORAL MUCOSITIS; BACTERIAL-INFECTION; CANCER; THERAPY; INNATE; PATHOBIOLOGY; CHEMOTHERAPY;

D O I：

10.1093/jac/dkp081

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The treatment of patients with cancer is often accompanied by life-threatening complications caused by chemotherapy and radiotherapy. They are known to result from neutropenia, but damage to the mucosal barrier as well as the humoral and cellular immune defences play a significant role in various infectious complications and aggravate diverse inflammatory processes. The article describes the journey from febrile neutropenia to febrile mucositis in patients treated with immunocompromising therapy.

引用

页码：I36 / I40

页数：5

共 44 条

[1] Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[2] Application of distance matrices to define associations between acute toxicities in colorectal cancer patients receiving chemotherapy [J].

Aprile, Giuseppe ;

Ramoni, Marco ;

Keefe, Dorothy ;

Sonis, Stephen .

CANCER, 2008, 112 (02) :284-292

[3]

Bellm LA, 2000, SUPPORT CARE CANCER, V8, P33

[4] Inferences, questions and possibilities in toll-like receptor signalling [J].

Beutler, B .

NATURE, 2004, 430 (6996) :257-263

[5] Prospective Oral Mucositis Audit: Oral mucositis in patients receiving high-dose melphalan or BEAM conditioning chemotherapy - European blood and marrow transplantation mucositis advisory group [J].

Blijlevens, Nicole ;

Schwenkglenks, Matthias ;

Bacon, Pamela ;

D'Addio, Alessandra ;

Einsele, Hermann ;

Maertens, Johan ;

Niederwieser, Dietger ;

Rabitsch, Werner ;

Roosaar, Ann ;

Ruutu, Tapani ;

Schouten, Harry ;

Stone, Rebecca ;

Vokurka, Samuel ;

Quinn, Barry ;

McCann, Shaun .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (09) :1519-1525

[6] Inflammatory response to mucosal barrier injury after myeloablative therapy in allogeneic stem cell transplant recipients [J].

Blijlevens, NMA ;

Donnelly, JP ;

DePauw, BE .

BONE MARROW TRANSPLANTATION, 2005, 36 (08) :703-707

[7] QUANTITATIVE RELATIONSHIPS BETWEEN CIRCULATING LEUKOCYTES AND INFECTION IN PATIENTS WITH ACUTE LEUKEMIA [J].

BODEY, GP ;

BUCKLEY, M ;

SATHE, YS ;

FREIREICH, EJ .

ANNALS OF INTERNAL MEDICINE, 1966, 64 (02) :328-+

[8] Contributions of mucosal immune cells to methotrexate-induced mucositis [J].

de Koning, Barbara A. E. ;

van Dieren, Jolanda M. ;

Lindenbergh-Kortleve, Dicky J. ;

van der Sluis, Maria ;

Matsumoto, Tetsuya ;

Yamaguchi, Keizo ;

Einerhand, Alexandra W. ;

Samsom, Janneke N. ;

Pieters, Rob ;

Nieuwenhuis, Edward E. S. .

INTERNATIONAL IMMUNOLOGY, 2006, 18 (06) :941-949

[9] Meta-analysis of randomized controlled trials of prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor after autologous and allogeneic stem cell transplantation [J].

Dekker, Allison ;

Bulley, Sean ;

Beyene, Joseph ;

Dupuis, L. Lee ;

Doyle, John J. ;

Sung, Lillian .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (33) :5207-5215

[10] Empirical and subsequent use of antibacterial agents in the febrile neutropenic patient [J].

DePauw, BE ;

Raemaekers, JMM ;

Schattenberg, T ;

Donnelly, JP .

JOURNAL OF INTERNAL MEDICINE, 1997, 242 :69-77

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