The many roles of PGC-1α in muscle - recent developments

被引：137

作者：

Chan, Mun Chun

Arany, Zolt

机构：

[1] Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USA

[2] Beth Israel Deaconess Med Ctr, Vasc Biol Res Ctr, Boston, MA 02215 USA

[3] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2014年 / 63卷 / 04期

关键词：

Muscle; Metabolism; PGC-1alpha; RECEPTOR-GAMMA COACTIVATOR-1-ALPHA; TERM CALORIC RESTRICTION; HUMAN SKELETAL-MUSCLE; FATTY-ACID OXIDATION; MITOCHONDRIAL BIOGENESIS; MESSENGER-RNA; GENE-EXPRESSION; TRANSCRIPTIONAL CONTROL; 1-ALPHA PGC-1-ALPHA; METABOLIC REGULATOR;

D O I：

10.1016/j.metabol.2014.01.006

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Skeletal muscle is the largest organ in the body and contributes to innumerable aspects of organismal biology. Muscle dysfunction engenders numerous diseases, including diabetes, cachexia, and sarcopenia. At the same time, skeletal muscle is also the main engine of exercise, one of the most efficacious interventions for prevention and treatment of a wide variety of diseases. The transcriptional coactivator PGC-1 alpha has emerged as a key driver of metabolic programming in skeletal muscle, both in health and in disease. We review here the many aspects of PGC-1 alpha function in skeletal muscle, with a focus on recent developments. (C) 2014 Elsevier Inc. All rights reserved.

引用

收藏

页码：441 / 451

页数：11

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