Elimination of the interferences by keto-opiates in the GC-MS analysis of 6-monoacetylmorphine

被引：1

作者：

Singh, J ^{[1
]}

Burke, RE ^{[1
]}

Mertens, LE ^{[1
]}

机构：

[1] Vet Affairs Med Ctr, Lab Serv 113, Minneapolis, MN 55417 USA

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 2000年 / 24卷 / 01期

关键词：

D O I：

10.1093/jat/24.1.27

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple procedure to eliminate the interference from keto-opiates in the analysis of 6-monoacetylmorphine (6-MAM) by gas chromatography-mass spectrometry is described. The pretreatment of urine samples with sodium bisulfite followed by solid-phase extraction results in the elimination of the bisulfite addition products formed from the reaction of the bisulfite ions with the carbonyl carbon of the keto-opiates. This simple procedure results in the accurate quantitation of 6-MAM at a concentration of 4 ng/mL in the presence of keto-opiates up to 10,000 ng/mL.

引用

页码：27 / 31

页数：5

共 8 条

[1]

Broussard LA, 1997, CLIN CHEM, V43, P1029

[2]

Cremese M, 1998, J FORENSIC SCI, V43, P1220

[3]

*DEP HLTH HUM SERV, 1998, FED REGISTER, V63, P63483

[4] A PROCEDURE FOR ELIMINATING INTERFERENCES FROM EPHEDRINE AND RELATED-COMPOUNDS IN THE GC/MS ANALYSIS OF AMPHETAMINE AND METHAMPHETAMINE [J].

ELSOHLY, MA ;

STANFORD, DF ;

SHERMAN, D ;

SHAH, H ;

BERNOT, D ;

TURNER, CE .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1992, 16 (02) :109-111

[5]

GOLDBERGER BA, 1993, CLIN CHEM, V39, P670

[6]

MORRISON RT, 1974, ORGANIC CHEM, P638

[7]

MULE SJ, 1988, CLIN CHEM, V34, P1427

[8] GAS-CHROMATOGRAPHY ELECTRON-IMPACT MASS FRAGMENTOMETRIC DETERMINATION OF URINARY 6-ACETYLMORPHINE, A METABOLITE OF HEROIN [J].

PAUL, BD ;

MITCHELL, JM ;

MELL, LD ;

IRVING, J .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1989, 13 (01) :2-7

← 1 →