A biopolymer by any other name would bind as well: A comparison of the ligand-binding pockets of nucleic acids and proteins

被引：17

作者：

Marshall, KA ^{[1
]}

Robertson, MP ^{[1
]}

Ellington, AD ^{[1
]}

机构：

[1] INDIANA UNIV,DEPT CHEM,BLOOMINGTON,IN 47405

来源：

STRUCTURE | 1997年 / 5卷 / 06期

关键词：

D O I：

10.1016/S0969-2126(97)00227-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Crystal structures have recently been reported for several in vitro selected aptamers that bind small molecules. A structural comparison of these aptamers with proteins that bind identical ligands reveals similar strategies for forming ligand-binding pockets.

引用

收藏

页码：729 / 734

页数：6

相关论文

共 29 条

[1] ISOLATION OF RNA APTAMERS FOR BIOLOGICAL COFACTORS BY IN-VITRO SELECTION [J].

BURGSTALLER, P ;

FAMULOK, M .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1994, 33 (10) :1084-1087

[2]

Cech TR, 1996, RNA, V2, P625

[3] RNA SELECTION - APTAMERS ACHIEVE THE DESIRED RECOGNITION [J].

ELLINGTON, AD .

CURRENT BIOLOGY, 1994, 4 (05) :427-429

[4] PARTITION OF TRANSFER-RNA SYNTHETASES INTO 2 CLASSES BASED ON MUTUALLY EXCLUSIVE SETS OF SEQUENCE MOTIFS [J].

ERIANI, G ;

DELARUE, M ;

POCH, O ;

GANGLOFF, J ;

MORAS, D .

NATURE, 1990, 347 (6289) :203-206

[5] Molecular recognition in the FMN-RNA aptamer complex [J].

Fan, P ;

Suri, AK ;

Fiala, R ;

Live, D ;

Patel, DJ .

JOURNAL OF MOLECULAR BIOLOGY, 1996, 258 (03) :480-500

[6] Aptamer structures from A to zeta [J].

Feigon, J ;

Dieckmann, T ;

Smith, FW .

CHEMISTRY & BIOLOGY, 1996, 3 (08) :611-617

[7]

FLETTERICK RJ, 1976, J BIOL CHEM, V251, P6142

[8] RNA aptamers that bind L-arginine with sub-micromolar dissociation constants and high enantioselectivity [J].

Geiger, A ;

Burgstaller, P ;

vonderEltz, H ;

Roeder, A ;

Famulok, M .

NUCLEIC ACIDS RESEARCH, 1996, 24 (06) :1029-1036

[9] DIVERSITY OF OLIGONUCLEOTIDE FUNCTIONS [J].

GOLD, L ;

POLISKY, B ;

UHLENBECK, O ;

YARUS, M .

ANNUAL REVIEW OF BIOCHEMISTRY, 1995, 64 :763-797

[10] STRUCTURAL FEATURES THAT GIVE RISE TO THE UNUSUAL STABILITY OF RNA HAIRPINS CONTAINING GNRA LOOPS [J].

HEUS, HA ;

PARDI, A .

SCIENCE, 1991, 253 (5016) :191-194