Dicaffeoylquinic acids alleviate memory loss via reduction of oxidative stress in stress-hormone-induced depressive mice

被引:37
作者
Lim, Dong Wook [1 ]
Park, Joon [1 ,2 ]
Jung, Jonghoon [4 ]
Kim, Su-Hyun [3 ,5 ]
Um, Min Young [1 ,2 ]
Yoon, Minseok [1 ]
Kim, Yun Tai [1 ,2 ]
Han, Daeseok [1 ]
Lee, Changho [1 ]
Lee, Jaekwang [1 ]
机构
[1] Korea Food Res Inst, Res Div Funct Food Functional, Wonju 55365, South Korea
[2] Univ Sci & Technol, KFRI Sch, Div Food Biotechnol, Daejeon 34113, South Korea
[3] Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Neurosci Program, Daejeon 34113, South Korea
[4] Korea Food Res Inst, Food Funct Evaluat Support Team, Wonju 55365, South Korea
[5] Korea Inst Sci & Technol, Ctr Neurosci, Brain Sci Inst, Seoul 02792, South Korea
关键词
Depression; Memory loss; Monoamine oxidase; Oxidative stress; Dicaffeoylquinic acid; Neuronal atrophy; ARCTIUM-LAPPA; VEGETABLE CONSUMPTION; CAFFEOYLQUINIC ACIDS; PLASTICITY; INHIBITOR; ROOTS; MANAGEMENT; MECHANISM; EXTRACT; BRAIN;
D O I
10.1016/j.phrs.2020.105252
中图分类号
R9 [药学];
学科分类号
100702 [药剂学];
摘要
Chronic stress can lead to depression due to elevated levels of stress hormones such as glucocorticoid. This is accompanied by an increase in reactive oxygen species (ROS) levels in the brain, which can cause dendritic spine loss and atrophy in neurons, followed by memory loss. Dicaffeoylquinic acids (diCQAs) are naturally occurring polyphenolic antioxidant compounds in Arctium lappa extracts (AL). The effects of natural derivatives of cafferoylqunic acid on stress hormone-induced depressive behavior and their underlying mechanisms are uncertain. In the current study, we showed that diCQAs reduced depressive behaviors including memory loss in corticosterone (CORT) treated mice. The mechanism of anti-depressants of diCQAs is likely through reduction of ROS production by inhibiting the activity of monoamine oxidase (MAO) type A and B in neurons and astrocytes. Among diCQAs, 3,4- and 3,5-diCQA significantly inhibited the activity of MAO enzymes followed by the reduction of ROS in neurons and astrocytes and also protected neuronal atrophy and synaptic transmission against stress hormone. These results suggest that 3,4- and 3,5-diCQAs effectively reduced depressive symptoms and inhibited ROS production to alleviate memory loss in stress hormone-induced depressive mice and hence, which provide some potential natural antidepressants.
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页数:12
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