Pro-inflammatory cytokines in acute coronary syndromes: From bench to bedside

被引：109

作者：

Tousoulis, Dimitris ^{[1
]}

Antoniades, Charalarnbos ^{[1
]}

Koumallos, Nikolaos ^{[1
]}

Stefanadis, Christodoulos ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Cardiol Unit 1, Athens 11528, Greece

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2006年 / 17卷 / 04期

关键词：

cytokines; acute coronary syndromes; plaque rupture;

D O I：

10.1016/j.cytogfr.2006.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytokines are produced in a variety of tissues and regulate the expression of a number of inflammatory molecules, leading to destabilization and finally rupture of vulnerable atheromatic plaques. They also participate in the pathophysiology of acute coronary syndromes (ACS) by direct effects on myocardial contractility and apoptosis. At a clinical level, circulating cytokines have a prognostic role since they are useful markers predicting future coronary events in patients with advanced atherosclerosis and in patients after ACS. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：225 / 233

页数：9

共 89 条

[1] CYTOKINES AND GROWTH-FACTORS POSITIVELY AND NEGATIVELY REGULATE INTERSTITIAL COLLAGEN GENE-EXPRESSION IN HUMAN VASCULAR SMOOTH-MUSCLE CELLS [J].

AMENTO, EP ;

EHSANI, N ;

PALMER, H ;

LIBBY, P .

ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (05) :1223-1230

[2] Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C [J].

Antoniades, C ;

Tousoulis, D ;

Tountas, C ;

Tentolouris, C ;

Toutouza, M ;

Vasiliadou, C ;

Tsioufis, C ;

Toutouzas, P ;

Stefanadis, C .

DIABETIC MEDICINE, 2004, 21 (06) :552-558

[3]

Antoniades C, 2003, HERZ, V28, P628, DOI 10.1007/s00059-003-2417-8

[4] Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina -: Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes [J].

Aukrust, P ;

Müller, F ;

Ueland, T ;

Berget, T ;

Aaser, E ;

Brunsvig, A ;

Solum, NO ;

Forfang, K ;

Froland, SS ;

Gullestad, L .

CIRCULATION, 1999, 100 (06) :614-620

[5] An essential role for NF-kappa B in preventing TNF-alpha-induced cell death [J].

Beg, AA ;

Baltimore, D .

SCIENCE, 1996, 274 (5288) :782-784

[6] Effects of captopril and omapatrilat on early post-myocardial infarction survival and cardiac hemodynamics in rats:: interaction with cardiac cytokine expression [J].

Blais, C ;

Lapointe, N ;

Rouleau, JL ;

Clément, R ;

Bachvarov, DR ;

Adam, A .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2002, 80 (01) :48-58

[7] Vascular inflammation and the renin-angiotensin system [J].

Brasier, AR ;

Recinos, A ;

Eledrisi, MS .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (08) :1257-1266

[8] Infectious and inflammatory stimuli decrease endothelial nitric oxide synthase activity in vitro [J].

Cardaropoli, S ;

Silvagno, F ;

Morra, E ;

Pescarmona, GP ;

Todros, T .

JOURNAL OF HYPERTENSION, 2003, 21 (11) :2103-2110

[9] Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE):: a randomised trial against atenolol [J].

Dahlöf, B ;

Devereux, RB ;

Kjeldsen, SE ;

Julius, S ;

Beevers, G ;

de Faire, U ;

Fyhrquist, F ;

Ibsen, H ;

Kristiansson, K ;

Lederballe-Pedersen, O ;

Lindholm, LH ;

Nieminen, MS ;

Omvik, P ;

Oparil, S ;

Wedel, H .

LANCET, 2002, 359 (9311) :995-1003

[10] Interleukin-7-mediated inflammation in unstable angina -: Possible role of chemokines and platelets [J].

Damås, JK ;

Wæhre, T ;

Yndestad, A ;

Otterdal, K ;

Hognestad, A ;

Solum, NO ;

Gullestad, L ;

Froland, SS ;

Aukrust, P .

CIRCULATION, 2003, 107 (21) :2670-2676

← 1 2 3 4 5 6 7 8 9 →