Progression of warfarin-associated intracerebral hemorrhage after INR normalization with FFP

被引：87

作者：

Lee, Sung B.

Manno, Edward M.

Layton, Kennith F.

Wijdicks, Eelco F. M.

机构：

[1] Mayo Clin Rochester, Div Crit Care Neurol, Coll Med, Dept Neurol, Rochester, MN 55905 USA

[2] Mayo Clin Rochester, Coll Med, Div Neuroradiol, Rochester, MN 55905 USA

来源：

NEUROLOGY | 2006年 / 67卷 / 07期

关键词：

D O I：

10.1212/01.wnl.0000238104.75563.2f

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To identify hematoma progression in patients with warfarin-associated intracerebral hemorrhage (ICH) despite international normalized ratio (INR) normalization with fresh-frozen plasma (FFP), we reviewed 45 patients with warfarin- associated ICH given FFP. The median time for door to INR normalization was 30 hours (14 to 49.5), with 4 patients' hematomas enlarging after INR normalization. FFP is associated with substantial time delay to actual administration and pulmonary edema and may not prevent progression of ICH despite INR normalization.

引用

页码：1272 / 1274

页数：3

共 9 条

[1] The pharmacology and management of the vitamin K antagonists
Ansell, J
Hirsh, J
Poller, L
Bussey, H
Jacobson, A
Hylek, E
[J]. CHEST, 2004, 126 (03) : 204S - 233S
[2] VOLUME OF INTRACEREBRAL HEMORRHAGE - A POWERFUL AND EASY-TO-USE PREDICTOR OF 30-DAY MORTALITY
BRODERICK, JP
BROTT, TG
DULDNER, JE
TOMSICK, T
HUSTER, G
[J]. STROKE, 1993, 24 (07) : 987 - 993
[3] Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage
Flibotte, JJ
Hagan, N
O'Donnell, J
Greenberg, SM
Rosand, J
[J]. NEUROLOGY, 2004, 63 (06) : 1059 - 1064
[4] Warfarin reversal
Hanley, JP
[J]. JOURNAL OF CLINICAL PATHOLOGY, 2004, 57 (11) : 1132 - 1139
[5] ORAL ANTICOAGULANTS AND INTRACRANIAL HEMORRHAGE - FACTS AND HYPOTHESES
HART, RG
BOOP, BS
ANDERSON, DC
[J]. STROKE, 1995, 26 (08) : 1471 - 1477
[6] Makris M, 1997, THROMB HAEMOSTASIS, V77, P477
[7] Transfusion and lung injury
Popovsky, MA
[J]. TRANSFUSION CLINIQUE ET BIOLOGIQUE, 2001, 8 (03) : 272 - 277
[8] The effect of warfarin and intensity of anticoagulation on outcome of intracerebral Hemorrhage
Rosand, J
Eckman, MH
Knudsen, KA
Singer, DE
Greenberg, SM
[J]. ARCHIVES OF INTERNAL MEDICINE, 2004, 164 (08) : 880 - 884
[9] PULMONARY-EDEMA AFTER TRANSFUSION WITH FRESH-FROZEN PLASMA
WYLD, PJ
WOODCOCK, BE
[J]. BRITISH MEDICAL JOURNAL, 1981, 282 (6269) : 1073 - 1074

← 1 →