Soluble polymer-supported synthesis of Biginelli compounds

被引：95

作者：

Xia, M ^{[1
]}

Wang, YG ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 43期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0040-4039(02)01850-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and general liquid-phase synthesis of Biginelli compounds has been developed. Polyethylene glycol (PEG) bound acetoacetate reacted with urea and aldehydes under reflux or solvent-free microwave irradiation conditions to afford PEG-supported 3,4-dihydropyrimidin-2(1H)-ones. The desired 3,4-dihydropyrimidin-2(1H)-ones were cleaved from the polymer support under mild conditions in high yields and high purity. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7703 / 7705

页数：3

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