An expanding job description for Blimp-1/PRDM1

被引：95

作者：

Bikoff, Elizabeth K. ^{[1
]}

Morgan, Marc A. ^{[1
]}

Robertson, Elizabeth J. ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2009年 / 19卷 / 04期

基金：

英国惠康基金;

关键词：

TRANSCRIPTIONAL REPRESSOR BLIMP-1; MATURATION PROTEIN-1 BLIMP-1; T-CELL HOMEOSTASIS; TERMINAL DIFFERENTIATION; NEURAL CREST; SET-DOMAIN; GENE; EXPRESSION; HEART; PRDI-BF1;

D O I：

10.1016/j.gde.2009.05.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The master transcriptional regulator Blimp-1/PRDM1 contains an N-terminal PR/SET domain and five C2H2 zinc fingers located near its C-terminus that mediate DNA binding, nuclear import and recruitment of histone modifying enzymes. These activities account for its ability to control cell-fate decisions in the embryo and govern tissue homeostasis in multiple cell types in the adult organism. New experiments demonstrate an increasing degree of complexity associated with Blimp-1/PRDM1 target site selection and its associations with epigenetic modifiers. Our current understanding of how this single unique species within the family of structurally similar PRDM proteins regulates gene expression patterns and governs developmental programmes in different cell lineages is discussed.

引用

页码：379 / 385

页数：7

共 56 条

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